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P142 Androgen Receptor Reduced Sensitivity is Associated with Cardiovascular Mortality in Men with Type 2 Diabetes - A 14-year Follow up Study

Year: 2020

Type: conference-abstract

Abstract: Background: Hypogonadism associates with increased cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM) [1].Increasing CAG repeat number within exon 1 of the androgen receptor gene associates with increased androgen receptor resistance/insulin resistance [2].We here investigated the link between CAG repeat number and metabolic/cardiovascular outcomes in T2DM men. Methods:We determined in a 14-year follow-up cohort of 274 T2DM Caucasian men in Salford UK, the association between baseline androgen status/CAG repeat number (determined by PCR followed by Sequenom sequencing) and metabolic trajectory plus mortality.Results: Lower baseline testosterone was associated with higher Body Mass Index (BMI) (kg/m 2 ) at 14-year follow-up: regression coefficient -0.30 (95% CI: -0.445 to -0.157), p = 0.0001 (total testosterone data) and higher HbA1c 2016.Higher baseline CAG repeat number associated with higher follow-up BMI in 2016 -each unit increase in CAG repeat associated with 0.43 increment in BMI 2016.At an average 14 year follow-up 55.8% of hypogonadal men had died vs 36.1% of eugonadal men (p = 0.001).72% of deaths were from cardiovascular causes.There was a 'u' shaped relation between the number of CAG repeats and mortality such that 21-23 CAG repeats was associated with an up to 58% lower mortality rate than <21 CAG repeats and >23 CAG repeats (Figure 1).This was independent of baseline testosterone.

Source: Artery Research

DOI: 10.2991/artres.k.191224.163