Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos–Investigation of Neurocognitive Aging Results (HCHS/SOL)
Year: 2020
Type: article
Abstract: OBJECTIVE Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos. RESEARCH DESIGN AND METHODS The Study of Latinos–Investigation of Neurocognitive Aging (SOL-INCA) is an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability-sampled (i.e., representative of targeted populations), and prospective cohort study. Between 2016 and 2018, SOL-INCA enrolled diverse Hispanics/Latinos aged ≥50 years (n = 6,377). Global cognitive decline and mild cognitive impairment (MCI) were the primary outcomes. RESULTS Prevalent diabetes at visit 1, but not incident diabetes at visit 2, was associated with significantly steeper global cognitive decline (βGC = −0.16 [95% CI −0.25; −0.07]; P < 0.001), domain-specific cognitive decline, and higher odds of MCI (odds ratio 1.74 [95% CI 1.34; 2.26]; P < 0.001) compared with no diabetes in age- and sex-adjusted models. CONCLUSIONS Diabetes was associated with cognitive decline and increased MCI prevalence among diverse Hispanics/Latinos, primarily among those with prevalent diabetes at visit 1. Our findings suggest that significant cognitive decline and MCI may be considered additional disease complications of diabetes among diverse middle-aged and older Hispanics/Latinos.
Source: Diabetes Care
DOI: 10.2337/dc19-1676
Institutions: University of California San Diego, Wayne State University, The University of Texas Health Science Center at Houston, University of North Carolina at Chapel Hill, San Diego State University, University of Illinois Chicago, Albert Einstein College of Medicine, Fred Hutch Cancer Center, University of Miami, Rush University Medical Center, University of California, Davis
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, Institut National Du Cancer, National Institutes of Health, Gillings School of Public Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G1004541261, G1042216835, G1081972346, G1301356587, G1312369436, Hispanic Community Health Study, G1455175283, Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), G1587824183, G1666450717, MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of Latinos, G1917633662, G2135211244, G2135293100, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2501967490, G2528054427, G2575730562, G2644289446, G2866617920, G2970637568, G3062787641, Hispanic Community Health Study, G3677686024, G3722034730, G3838006641, G3952816605, G4121762840, Hispanic Community Health Study, G4421869008, G4552920371, G4860668542, G4989378220, G528357465, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G543802643, G555858244, G5739677117, G5878028785, G5906656038, G5935820280, G6075306088, G6156511736, Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse Latinos, G6585687856, G6744188800, G6914194341, G7057037114, G7203655167, G7239480477, G7272721675, G7278742613, G7408420985, Scripps Translational Science Institute, G7513901258, G7678550560, G7685783422, Diabetes Research and Training Center, Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR), G8102260223, G820454163, G8386326007, G8840902395, G8904081916, G8932431361, G9000199330, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, NYR-Diabetes Research Center (NYR-DRC), San Diego Alzheimer's Disease Resource Center for Minority Aging Research (San Diego AD-RCMAR), New York Regional Center for Diabetes Translation Research
OpenAlex ID: W3009168032