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Sat-458 Primary Hyperaldosteronism and Renal Calculi: Accidental Association or Cause and Effect Relationship

Year: 2020
Type: conference-abstract
Abstract: The association between primary hyperaldosteronism and urolithiasis is rarely reported. Hypercalciuria and / or hyperoxaluria seem to be the cause of stones. We report two cases of primary hyperaldosteronism who were diagnosed while etiological investigation of nephrolithiasis disease. Case 1: This is a 53-year-old man followed since 20 years for renal stones revealed by nephritic colic. On clinical examination, his weight was 99 kg and blood pressure was 180/120 mmHg. The metabolic investigations revealed a serum potassium level of 3.9 mmol / l, creatinine clearance of 97.5 ml / min, kaliuresis at 88 mmol / l and hyperoxaluria associated with hypocitraturia without urinary tract infection. Lithiasis was oxalodependant. Hormonal exploration showed an aldosterone- renin ratio at 400 pmol / mIU. Computed tomography scan showed bilateral adrenal enlargment. Case 2: This is a 15 year old boy admitted for etiological assessment of nephrocalcinosis. Clinical examination has shown severe hypertension associated with deep hypokalemia (2.5mmol / l). Metabolic assessment revealed hypercalciuria, hyperoxaluria and hypocitraturia. The aldosterone- renin ratio was 327pmol / mIU. The adrenal scan was normal, but the adrenal scintigraphy showed a focused hyperfixation on the right adrenal gland. The patient underwent right adrenalectomy by laparoscopy, and histopathological examination showed adrenal adenoma. The association of hypertension with renal calculi can be explained by the same anomaly, in particular primary hyperaldosteronism.
DOI: 10.1016/j.ekir.2020.02.487
Authors: H. DAOUD, A. Harzallah, R. Karray, H. Kaaroud, B. Fendri, I. Ben Nacef, F. Ben Hmida, K. Khiari, M. Ounissi, T. Ben Abdallah
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,625
OpenAlex ID: W3011362829
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