Work

Effect of Propranolol with and without Rosuvastatin on Migraine Attacks: A Triple Blind Randomized Clinical Trial

Year: 2020

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Aim: To investigate the effect of rosuvastatin in combination with propranolol in reducing migraine attacks. Patients & methods: In a clinical trial study with census method, 120 patients with migraine headache were included. Patients were randomly assigned (using block randomization) to either propranolol (10 mg twice a day) with rosuvastatin (10 mg daily; intervention group [n = 60]) or propranolol (10 mg twice a day) with placebo (control [n = 60]). Results: The numbers of attacks were significantly decreased in the intervention group at the end of second, third and fourth weeks from the beginning of the intervention (p < 0.05). Conclusion: In patients with migraine, concomitant administration of propranolol (10 mg twice a day) and rosuvastatin (10 mg daily) is effective in reducing migraine attacks.

Source: Future Neurology

DOI: 10.2217/fnl-2019-0029

Authors: Mehrdokht Mazdeh, Rihane Mahmudian, Seyed Y Vafaei, Mohammad Taheri, Soudeh Ghafouri-Fard

Institutions: Hamedan University of Medical Sciences, Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Migraine and Headache Studies

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3012246972

FWCI: 3.742

Cites: 29

Cited by: 24

Related to: 10