Work

Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis

Year: 2020

Type: article

Abstract: The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-κB activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central nervous system, and its involvement in developing potential therapeutic targets.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2020.00391

Authors: Yifan Zhou, Chunping Cui, Xiaoyu Ma, Wenjing Luo, Song Guo Zheng, Wei Qiu

Institutions: Third Affiliated Hospital of Sun Yat-sen University, The Ohio State University Wexner Medical Center

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950