Work

The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks

Year: 2020

Type: article

Abstract: dependent, requires the DNA polymerase δ and PCNA modification at K164, and is enabled by Esc2 and the PCNA unloader Elg1, being inhibited when Mgs1 is present. We propose that Mgs1 is necessary to prevent a potentially toxic recombination salvage pathway at sites of perturbed replication, which, in turn, favors Rad5-dependent template switching, thus helping to preserve genome stability.

Source: Science Advances

DOI: 10.1126/sciadv.aaz3327

Authors: Alberto Jiménez-Martín, Irene Saugar, Chinnu Rose Joseph, Alexandra Mayer, Carl P. Lehmann, Barnabas Szakal, Dana Branzei, José Antonio Tercero

Institutions: Consejo Superior de Investigaciones Científicas, Centro de Biología Molecular Severo Ochoa, IFOM, Istituto di Genetica Molecolare, National Research Council

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $4,500

Funders: Associazione Italiana per la Ricerca sul Cancro, European Research Council

Award: G1108531686

OpenAlex ID: W3015494569

FWCI: 0.786

Cites: 40

Cited by: 15

Related to: 10