Work

Light-activated gold nanorod vesicles with NIR-II fluorescence and photoacoustic imaging performances for cancer theranostics

Year: 2020

Type: article

Abstract: Fluorescence (FL) and photoacoustic (PA) imaging in the second near infrared window (NIR-II FL and NIR-II PA) hold great promise for biomedical applications because of their non-invasive nature and excellent spatial resolution properties.Methods: We develop a NIR-II PA and NIR-II FL dual-mode imaging gold nanorod vesicles (AuNR Ves) by self-assembly of amphiphilic AuNR coated with light responsive polyprodrug of Ru-complex and PEG, and NIR-II cyanine dye (IR 1061).The AuNR Ves showed strong ligh absorption property and PA imaging performance in the NIR-II windows.Moreover, the NIR-II fluorescence signal of IR 1061 loaded in the AuNR Ve is quenched.Results: The AuNR Ves can release photosensitizer Ru-complex and IR 1061 sequentially triggered by NIR light irradiation, leading to a corresponding NIR-II PA signal decrease and NIR-II FL signal recovery.Meanwhile, Ru-complex can not only serve as a chemotherapeutic drug but also generate singlet oxygen ( 1 O2) under NIR light irradiation.The release of Ru-complex and photodynamic therapy are guided by the responsive variation of NIR-II PA and NIR-II FL signals.Conclusions: The AuNR Ve possessing not only precisely control 1 O2/drug release but also the intrinsic ability to monitor therapy process offers a new strategy for the development of smart theranostic nanoplatform.

Source: Theranostics

DOI: 10.7150/thno.44376