Work

Photochemically Mediated Nickel-Catalyzed Synthesis of N -(Hetero)aryl Sulfamides

Year: 2020

Type: article

Abstract: A general method for the N-arylation of sulfamides with aryl bromides is described. The protocol leverates a dual-catalytic system of nickel and a photoexcitable iridium complex and proceeds at room temperature under visible light irradiation. Using these tactics, aryl boronic esters and aryl chlorides can be carried through the reaction untouched. Thereby, this method complements known Buchwald-Hartwig coupling methods for N-arylation of sulfamides.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.0c00139

Authors: R. Thomas Simons, Georgia E. Scott, Anastasia Gant Kanegusuku, Jennifer L. Roizen

Institution: Duke University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green