Uso de resúmenes de evidencia para informar el tratamiento farmacológico de personas con sospecha o diagnóstico de infección respiratoria por SARS CoV-2 / COVID-19
Year: 2020
Type: article
Study design: Systematic Review
Abstract: Introduction: Due to the emergence of the SARS-CoV-2 coronavirus since December 2019, a large volume of scientific production has been generated, in some cases uncertain or controversial, especially in the pharmacological management of patients with this infection; therefore, it is considered a relevant search for methodological alternatives to carry out its rigorous, systematic and quality synthesis, but with less execution time and lower cost. Objective: To present the available evidence regarding the pharmacological management of people with suspected or diagnosed respiratory SARS-CoV-2 (COVID-19) using the method of rapid systematic reviews (RS-R) in potentially effective drugs for their management. Methodology: A systematic and structured search was conducted in Medline, Embase, Scopus, Cochrane Library, Clinical trials and Google Scholar in English. Studies included clinical practice guidelines, consensus, systematic reviews, meta-analyses, clinical trials, and other primary studies. Data search and extraction were performed by multiple reviewers, but none were paired. Results: Sixteen questions of clinical interest were resolved, related to the use in COVID-19 of lopinavir/ritonavir, nelfinavir, oseltamivir, remdesivir, ribavirin, teicoplanin, umifenovir, favipiravir, tocilizumab, ivermectin, convalescent plasma; the use of support management drugs such as dexamethasone were also evaluated, as well as the concomitant use of drugs that generated doubts, such as NSAIDs, ACEis, and ARA IIs. Conclusions: Summaries of evidence are within the pandemic scenario as a good methodological alternative to offer quality information in the short term for decision-makers.
Source: Revista Colombiana de Nefrología
Authors: Nancy Yomayusa González, Eduardo Low Padilla, Ilich De La Hoz Siegler, Kelly Chacón, Juan Acevedo Peña, Liliana Barrero Garzón, Alexander Barrera, Natalia Tolosa, Andrea Castillo, Fredy Guevara Pulido, Diana Castelblanco, Carlos Pinzón Florez, Fredy Mendivelso Duarte, Francy Cantor Cruz, Ana Castillo Gutiérrez, Olga Gómez Gómez, Adriana Ávila, Claudia Guevara, Carlos Álvarez Moreno, José Rojas Gambasica, Carlos Miguel Arbeláez Duque, Bibiana García Guarín, Martha Cárdenas Rodríguez, Sandra Robayo Rodríguez, Marcela Torres Castro
Language: Spanish
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3019722902