17beta estradiol ameliorates neuroinflammation driven neuropathic pain in chronic constriction injury – induced peripheral neuropathy in rats
Year: 2019
Type: article
Abstract: 17beta estradiol ameliorates neuroinflammation driven neuropathic pain in chronic constriction injuryinduced peripheral neuropathy in rats AbstrAct background.Accumulating evidence illustrates that peripheral nerve injuries ac-tivate glial components of the peripheral and central cellular circuitry which contributes to neuroinflammation and neuropathic pain.Epidemiological surveys suggest that for women the prevalence of pain increases with age with more frequent pain than men.Recently, several studies have found that pain generation, transmission and modulation are under hormonal regulation.To this end, 17beta estradiol was used to investigate the modulatory actions on nociceptive thresholds in neuroinflammation driven neuropathic pain conditions.Methods.Adult female Wistar rats were divided into four groups: Ovariectomised neuropathic untreated and neuropathic 17 beta estradiol treated groups.sham operated and intact control groups.results.In treated rats, the results validate an anti-inflammatory action of 17 beta estradiol against chronic constriction injury (CCI) induced neuropathic pain by attenuat-ing complement C3 fractions and anti-neutrophil cytoplasmic auto-antibodies (ANCAs) intensity plasma level, an anti-nociceptive action by attenuating ipsilateral, con-trolateral allodynia and hyperalgesia developed in treated animals after chronic con-striction injury and at the last day of treatment by increasing the tail flick latency at the last day of treatment.conclusions.We conclude that 17beta estradiol might exhibit beneficial effects on peripheral nerve injury consequences.
Source: Romanian Journal of Neurology
Authors: Nafissa Telailia, Hacène Frih, Sylvain Fisson, INSERM, UMR_S951, Evry, France, Genethon, Evry, France
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3020552003