Work

Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water

Year: 2020

Type: article

Abstract: We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202005902

Authors: Weijian Xue, Peter Y. Zavalij, Lyle Isaacs

Institution: University of Maryland, College Park

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institute of General Medical Sciences

Awards: Cucurbituril Type Receptors as Sequestration Agents for Drugs of Abuse, Synthesis and Application of Cucurbit[n]uril Type Receptors