Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease
Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUND: mutations represent well established risk factors of CD, the role of other genes is incompletely understood. AIM: , two members of the C-type lectin domain family of pattern recognition receptors, may be associated with CD. METHODS: were studied using real time PCR-based SNP assays. Therefore, DNA samples from 175 patients and 157 healthy donors were employed. Genotyping data were correlated with clinical characteristics of the patients and the results of gene expression data analyses. RESULTS: , suggesting of a novel pathway contributing to the disease. CONCLUSION: with CD. The C-type lectin domain family member also deserves attention regarding a potential role in the pathophysiology of CD.
Authors: Nagi Elleisy, Sarah Rohde, Astrid Huth, Nicole Gittel, Änne Glass, Steffen Möller, Georg Lamprecht, Holger Schäffler, Robert Jaster
Institutions: Universitätsmedizin Rostock, University of Rostock
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W3024936680