Work

Systematic Investigations on Continuous Fluidized Bed Crystallization for Chiral Separation

Year: 2020

Type: article

Abstract: A recently developed continuous enantioseparation process utilizing two coupled fluidized bed crystallizers is systematically investigated to identify essential correlations between different operation parameters and the corresponding process performance on the example of asparagine monohydrate. Based on liquid phase composition and product crystal size distribution data, it is proven that steady state operation is achieved reproducibly in a relatively short time. The process outputs at steady state are compared for different feed flow rates, supersaturations, and crystallization temperatures. It is shown that purities >97% are achieved with productivities up to 40 g/L/h. The size distribution, which depends almost exclusively on the liquid flow rate, can be easily adjusted between 260 and 330 µm (mean size) with an almost constant standard deviation of ±55 µm.

Source: Crystals

DOI: 10.3390/cryst10050394

Authors: Erik Temmel, Jonathan Gänsch, Andreas Seidel-Morgenstern, Heike Lorenz

Institutions: Sulzer (Switzerland), Max Planck Institute for Dynamics of Complex Technical Systems, Otto-von-Guericke-Universität Magdeburg

Language: English

Topic: Crystallization and Solubility Studies

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,690

Funder: Deutsche Forschungsgemeinschaft