Recurrent metastatic clear cell renal carcinoma with sarcomatoid dedifferentiation treated with surgery and Cabozantinib
Year: 2020
Type: article
Study design: Case Report
Abstract: // Johnny Boustany 1 , 2 , Maher Abdessater 1 , 2 , Charbel El Hachem 1 , 2 , Ziad El Khoury 1 , 2 , Walid El Khoury 1 , 2 and Raghid El Khoury 1 , 2 1 Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, Lebanon 2 Holy Spirit University of Kaslik (USEK), Jounieh, Lebanon Correspondence to: Johnny Boustany, email: [email protected] Keywords: clear cell renal carcinoma; sarcomatoid dedifferentiation; metastasectomy; cabozantinib Received: December 09, 2019 Accepted: March 14, 2020 Published: May 19, 2020 ABSTRACT Renal cell carcinoma with sarcomatoid dedifferentiation is an entity of RCC that has undergone an anaplastic transformation with both a carcinomatous and a sarcomatous component. The standard treatment in metastatic patients is immunotherapy. The aim of this article is to describe our case of metastatic recurrent RCC with sarcomatoid dedifferentiation in a 59 year old male patient treated with nephrectomy and multiple metastasectomies followed by Cabozantinib. Consecutive PET-CT scans showed no evidence of recurrence, three years after the last metastasectomy, and the patient is having currently a normal life. Sarcomatoid dedifferentiation remains a poor prognosis factor in RCC. Surgery for metastases followed by Cabozantinib may be a therapeutic option in metastatic young patients. However, a prospective randomized trial would be the best option to validate this approach.
Source: Oncotarget
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3026054864