Work

High incidence invasive breast cancer is associated with Her2/neu(+)/ER(+)/PR(+) and high grade ductal carcinoma in young age patients of NortheastIndia

Year: 2020

Type: article

Abstract: Breast cancer prognosis depends on age, histologic type, grade and lymph node metastasis. Treatment protocol is surgery, chemotherapy and radiotherapy followed by adjuvant therapy. Adjuvant therapy is determined by expression of Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Receptor (Her2/neu) on the cancer cells. The study aims to evaluate the ER, PR and Her-2/neu expression in invasive breast carcinomas by Immunohistochemistry (IHC) and to compare the pattern of expression with clinicopathological parameters like patient's age, histological type, grade and lymph node metastasis. This is a retrospective study of newly diagnosed 182 female who have undergone modified radical mastectomy with axillary clearance for invasive breast cancer. Typing and grading of tumour was done on haematoxylin and eosin stained sections. IHC was done to evaluate expression of ER, PR and Her2/neu. Statistical analysis was done by chi-square and Z-test. The age of patients ranged from 23 to 85 years. The most common type of tumour is Infiltrating ductal carcinoma grade 2 (50.8%), followed by grade 1 (39%). ER, PR and Her2/neu expression was found in 52%, 46% and 43% cases, respectively. Hormonal receptor positivity and Her2/neu overexpression was observed more in younger age group. Lymph node metastasis is more common in younger age group and higher grade tumour. In this study, young age group women are more prone to Breast Cancer and the IDC is significant. The hormonal receptors as well as Her2 positive status reveals that a well-designed therapeutic strategy will confer recovery of the patients.

Source: Current Medicine Research and Practice

DOI: 10.1016/j.cmrp.2020.05.006

Authors: C. Lalchhandama, Lalawmpuii Pachuau, Tlau Lalchhanhimi, John Zohmingthanga, Nachimuthu Senthil Kumar

Institutions: Government of Mizoram, Mizoram University, Aizawl Adventist Hospital

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000