Spirometry performed as part of the Manchester community-based lung cancer screening programme detects a high prevalence of airflow obstruction in individuals without a prior diagnosis of COPD
Year: 2020
Type: article
Study design: Observational Study
Abstract: Background COPD is a major cause of morbidity and mortality in populations eligible for lung cancer screening. We investigated the role of spirometry in a community-based lung cancer screening programme. Methods Ever smokers, age 55–74, resident in three deprived areas of Manchester were invited to a ‘Lung Health Check’ (LHC) based in convenient community locations. Spirometry was incorporated into the LHCs alongside lung cancer risk estimation (Prostate, Lung, Colorectal and Ovarian Study Risk Prediction Model, 2012 version (PLCO M2012 )), symptom assessment and smoking cessation advice. Those at high risk of lung cancer (PLCO M2012 ≥1.51%) were eligible for annual low-dose CT screening over two screening rounds. Airflow obstruction was defined as FEV 1 /FVC<0.7. Primary care databases were searched for any prior diagnosis of COPD. Results 99.4% (n=2525) of LHC attendees successfully performed spirometry; mean age was 64.1±5.5, 51% were women, 35% were current smokers. 37.4% (n=944) had airflow obstruction of which 49.7% (n=469) had no previous diagnosis of COPD. 53.3% of those without a prior diagnosis were symptomatic (n=250/469). After multivariate analysis, the detection of airflow obstruction without a prior COPD diagnosis was associated with male sex ( adj OR 1.84, 95% CI 1.37 to 2.47; p<0.0001), younger age (p=0.015), lower smoking duration (p<0.0001), fewer cigarettes per day (p=0.035), higher FEV 1 /FVC ratio (<0.0001) and being asymptomatic ( adj OR 4.19, 95% CI 2.95 to 5.95; p<0.0001). The likelihood of screen detected lung cancer was significantly greater in those with evidence of airflow obstruction who had a previous diagnosis of COPD ( adj OR 2.80, 95% CI 1.60 to 8.42; p=0.002). Conclusions Incorporating spirometry into a community-based targeted lung cancer screening programme is feasible and identifies a significant number of individuals with airflow obstruction who do not have a prior diagnosis of COPD.
Source: Thorax
Authors: Haval Balata, Jonathan Harvey, Phil V Barber, Denis Colligan, Rebecca Duerden, Peter Elton, Matthew Evison, Melanie Greaves, John Howells, Klaus Irion, Devinda Karunaratne, Stuart Mellor, Tom Newton, Richard Sawyer, Anna Sharman, Elaine Smith, Ben Taylor, Sarah Taylor, Janet Tonge, Anna Walsham, James Whittaker, Joergen Vestbo, Richard Booton, Phil A Crosbie
Institutions: University of Manchester, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Greater Manchester Health & Social Care Partnership, Royal Preston Hospital, Manchester Royal Infirmary, Royal Blackburn Teaching Hospital, The Christie Hospital, The Christie NHS Foundation Trust, Salford Royal NHS Foundation Trust, Salford Royal Hospital, Stockport NHS Foundation Trust
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W3027872602