Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study
Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Bronchiolitis is the leading cause of infant hospitalizations in the United States. Growing evidence supports the heterogeneity of bronchiolitis. However, little is known about the interrelationships between major respiratory viruses (and their species), host systemic metabolism, and disease pathobiology. METHODS: In an ongoing multicenter prospective cohort study, we profiled the serum metabolome in 113 infants (63 RSV-only, 21 RV-A, and 29 RV-C) hospitalized with bronchiolitis. We identified serum metabolites that are most discriminatory in the RSV-RV-A and RSV-RV-C comparisons using sparse partial least squares discriminant analysis. We then investigated the association between discriminatory metabolites with acute and chronic outcomes. RESULTS: < 0.05). In the RSV-RV-A comparison, we identified 30 discriminatory metabolites, predominantly in lipid metabolism pathways (eg, sphingolipids and carnitines). In multivariable models, these metabolites were significantly associated with the risk of clinical outcomes (eg, tricosanoyl sphingomyelin, OR for recurrent wheezing at age of 3 years = 1.50; 95% CI: 1.05-2.15). In the RSV-RV-C comparison, the discriminatory metabolites were also primarily involved in lipid metabolism (eg, glycerophosphocholines [GPCs], 12,13-diHome). These metabolites were also significantly associated with the risk of outcomes (eg, 1-stearoyl-2-linoleoyl-GPC, OR for positive pressure ventilation use during hospitalization = 0.47; 95% CI: 0.28-0.78). CONCLUSION: Respiratory viruses and their species had distinct serum metabolomic signatures that are associated with differential risks of acute and chronic morbidities of bronchiolitis. Our findings advance research into the complex interrelations between viruses, host systemic response, and bronchiolitis pathobiology.
Source: Pediatric Allergy and Immunology
DOI: 10.1111/pai.13296
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Airway dual-transcriptomics in bronchiolitis and risk of asthma: MARC-35 cohort, Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort, Host genetics, early-life microbiome, and childhood asthma: MARC-43 Boston, Cytokines & transcriptomes in rhinovirus bronchiolitis and risk of incident asthma, Infant specific-IgE, rhinovirus-C bronchiolitis, and incident asthma in MARC-35, Viral persistence & the microbiome in bronchiolitis and risk of recurrent wheeze, Airway metagenome & metabolome in bronchiolitis and risk of asthma: MARC-35 cohort, Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent Wheezing, G9000073196, Host genetics, early-life microbiome, and childhood asthma: MARC-43 Boston, Interactions Between the Microbiome, Immunity and Respiratory Health in Traditional Agrarian and Suburban children
OpenAlex ID: W3028660484