Work

Regulation of the blood circulation by selective inhibitors of nitric oxide synthesis in experimental haemorrhagic shock

Year: 2010

Type: article

Abstract: The results in volume-controlled haemorrhagic shock in rats demonstrated that selective inhibitors of nitric oxide synthases (derivates of the lysine, ornithine, guanidine, S-methylisothiourea) considerably enhanced the efficiency of infusion therapy. All these selective inhibitors induced improvement of cardiac work (increased stroke volume, cardiac output, left ventrical work). The more visible effect was revealed using N-5-(iminoethyl)-L-ornithine and aminoguanidine.These agents have demonstrated the most pronounced correction of the cardiovascular system indexes and 100% survival of animals.

Source: Medical academic journal

DOI: 10.17816/maj10157-63

Authors: M I Remizova, K A Gerbout, G V Grishina, N I Kochetygov

Institution: Russian Research Institute of Hematology and Transfusiology

Language: English

Topic: Trauma, Hemostasis, Coagulopathy, Resuscitation

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W3028831757

FWCI:

Cites: 13

Cited by: 1

Related to: 10