Year: 2020
Type: preprint
Abstract: In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date it has resulted in ~5.6 million confirmed cases and caused 353,334 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socio-economic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a “cytokine storm” leading to acute respiratory distress syndrome, endothelitis, thrombo-embolic complications and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. Over 140 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.
Authors: CARMEN RIGGIONI, Pasquale Comberiati, Mattia Giovannini, Ioana Agache, Mubeccel Akdis, Magna Alves-Correia, Josep Anto, Alessandra Arcolaci, Ahmet Azkur, Dilek Azkur, Burcin Beken, Cristina Boccabella, Jean Bousquet, Heimo Breiteneder, Daniela Carvalho, Leticia De las Vecillas, Zuzana Diamant, Ibon Eguiluz-Gracia, Thomas Eiwegger, Stefanie Eyerich, Wytske Fokkens, Ya-dong Gao, Farah Hannachi, Sebastian Johnston, Marek Jutel, Aspasia Karavelia, Ludger Klimek, Beatriz Moya, Kari Nadeau, Robin O'Hehir, Liam O'Mahony, Oliver Pfaar, Marek Sanak, Jürgen Schwarze, Milena Sokolowska, María José Torres, Willem Van de Veen, Menno van Zelm, De Yun Wang, Luo Zhang, Rodrigo Jimenez-Saiz, Cezmi Akdis
Institutions: Hospital Sant Joan de Déu Barcelona, University of Verona, Beijing Tongren Hospital, National University of Singapore, Capital Medical University, Transilvania University of Brașov, University of Zurich, Universidade do Porto, Barcelona Institute for Global Health, Kırıkkale University, Trakya University, Università Cattolica del Sacro Cuore, Université de Versailles Saint-Quentin-en-Yvelines, Medical University of Vienna, University of Lisbon, Marqués de Valdecilla University Hospital, Skåne University Hospital, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga, Great Ormond Street Hospital, Hospital for Sick Children, Helmholtz Munich, Technical University of Munich, University of Amsterdam, Wuhan University, Zhongnan Hospital of Wuhan University, Centre Hospitalier de Luxembourg, Imperial College London, Wroclaw Medical University, Chania General Hospital ”St. George”, Zentrum für Rhinologie und Allergologie, Hospital Universitario 12 De Octubre, Stanford University, Monash University, National University of Ireland, University College Cork, Philipps University of Marburg, Jagiellonian University, University of Edinburgh, National Center for Biotechnology
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3035201082