Work

Effects of polysaccharides from bee collected pollen of Chinese wolfberry on immune response and gut microbiota composition in cyclophosphamide-treated mice

Year: 2020

Type: article

Abstract: The gut microbiota has emerged as an important contributor to the immune system and it is believed to be regulated by dietary fiber. In this study, therefore, the immunomodulatory and gut microbiota modulatory effects of polysaccharides from bee collected pollen of Chinese wolfberry (WBPPS) in cyclophosphamide (CTX)-treated mice were investigated. The results showed that WBPPS could enhance thymus and spleen indices and promote production of immune-related cytokines (IgA, TNF-α, TGF-β1 and IL-10) in serum of CTX-treated mice. In addition, WBPPS could significantly improve hepatic function and oxidative stress in CTX-treated mice via increasing the levels of GSH, SOD and CAT and decreasing the levels of ALT and MDA. More importantly, WBPPS remarkably increased the relative abundances of Family_XIII, Ruminococcaceae and Saccharimonadaceae while decreased the relative abundances of Tannerellaceae, Marinifilaceae and Rikenellaceae, which were closely associated with immune traits. Overall, WBPPS might be developed as a promising immunomodulator in functional foods.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2020.104057