Year: 2020
Type: article
Study design: Observational Study
Abstract: Acute lymphoblastic leukemia (ALL) is a malignant proliferation of lymphoid cells characterized as a heterogeneous disease at demographic, clinical and genetic levels. Copy number alterations (CNAs) are defined as secondary abnormalities subsequently required for the establishment of the leukemic clone. As the risk stratification of ALL is partly based on genetic analysis, different genomic tools are increasingly being used to screen for novel genetic biomarkers. In the present study, through array‑comparative genomic hybridization (aCGH), CNAs in 12 ADAM genes were investigated and their association with clinicopathological features in 16 pediatric ALL cases was evaluated. The most frequent amplification was found in ADAM6 (94%), and deletion was more common in ADAM3A (31%). ADAM3A deletion were associated with male patients (P=0.025), leukocytosis (P=0.007) and high‑risk cases (P=0.004). However, the effects of aberration on ADAM genes still needs to be fully defined in hematological malignancies, particularly in leukemia. The findings of the present study corroborate those of previous studies that suggest that ADAM genes play a role in carcinogenesis.
DOI: 10.3892/wasj.2020.56
Institutions: Universidade Federal do Pará, Instituto Evandro Chagas
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G29316538, G4180829881
OpenAlex ID: W3036089421