Work

Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice

Year: 2020

Type: article

Abstract: The premise of this study was to examine the efficacy of genetic suppression of mitochondrial reactive oxygen species (ROS) to attenuate disuse-induced muscle atrophy and muscle weakness. Neutralization of mitochondrial ROS by MCAT expression was insufficient to rescue muscle atrophy and muscle weakness.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00456.2019

Authors: Hiroaki Eshima, Piyarat Siripoksup, Ziad S. Mahmassani, Jordan M. Johnson, Patrick J. Ferrara, Anthony R. P. Verkerke, Anahy Salcedo, Micah J. Drummond, Katsuhiko Funai

Institution: University of Utah

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, Uehara Memorial Foundation, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Mitochondrial phospholipids, ROS, and disuse atrophy, Novel molecular mechanisms of skeletal muscle insulin resistance in physically inactive older adults, G3947751822, Skeletal muscle mitochondrial phospholipids and aerobic capacity., Linking Phosphatidylcholine Synthesis to Thermogenesis, Muscle phospholipid methylation modulates SERCA energy efficiency to alter susceptibility for obesity, Novel molecular mechanisms of skeletal muscle insulin resistance in physically inactive older adults, Cardiovasomobility Research Training Program, Mitochondrial membrane lipids and respiratory efficiency, Diabetes Research Center

OpenAlex ID: W3036985808

FWCI: 1.213

Cites: 54

Cited by: 32

Related to: 10