Aspects of the pathogenesis of vesicular lesions of the oral mucosa
Year: 2018
Type: article
Study design: Observational Study
Abstract: The possibility of using immunohistochemical study and the method of tissue PCR in the complex diagnosis of vesicular lesions of the oral mucosa has been studied. A total clinical and laboratory examination included 57 patients, including: patients with pemphigoid bullosa (32), pemphigus vulgaris (25). Results of immunohistochemical study indicate cellular mechanisms of epithelial damage, in which IgG, C3d fragments of the complement take part, receptors for cytokine-2, as well as antibodies against E-cadherin protein. Identification of microorganisms in pathologically altered tissues by the method of PCR should be regarded as one of the triggers of the antigenic factor in the vesicular lesions of the oral mucosa. The obtained data convincingly prove the necessity of application of these methods in complex diagnostics of vesicular lesions of the oral mucosa.
Source: Clinical Dentistry (Russia)
Language: Russian
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3038439619