Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis
Year: 2020
Type: article
Abstract: BACKGROUND: The Sarcopenia Definitions and Outcomes Consortium (SDOC) sought to identify cut points for muscle strength and body composition measures derived from dual-energy x-ray absorptiometry (DXA) that discriminate older adults with slow walking speed. This article presents the core analyses used to guide the SDOC position statements. DESIGN: Cross-sectional data analyses of pooled data. SETTING: University-based research assessment centers. PARTICIPANTS: Community-dwelling men (n = 13,652) and women: (n = 5,115) with information on lean mass by DXA, grip strength (GR), and walking speed. MEASUREMENTS: Thirty-five candidate sarcopenia variables were entered into sex-stratified classification and regression tree (CART) models to agnostically choose variables and cut points that discriminate slow walkers (<0.80 m/s). Models with alternative walking speed outcomes were also evaluated (<0.60 and <1.0 m/s and walking speed treated continuously). RESULTS: . Women with GRTBF of less than 0.65 kg/kg were twice as likely to be slow walkers than women with GRTBF of 0.65 kg/kg or greater. Models with alternative walking speed outcomes selected only functions of GR as primary discriminators of slowness in both men and women. DXA-derived lean mass measures did not consistently discriminate slow walkers. CONCLUSION: GR with and without adjustments for body size and composition consistently discriminated older adults with slowness. CART models did not select DXA-based lean mass as a primary discriminator of slowness. These results were presented to an SDOC Consensus Panel, who used them and other information to develop the SDOC Position Statements. J Am Geriatr Soc 68:1419-1428, 2020.
DOI: 10.1111/jgs.16524
Authors: Todd M. Manini, Sheena M. Patel, Anne B. Newman, Thomas G. Travison, Douglas P. Kiel, Michelle D. Shardell, Karol M. Pencina, Kevin E. Wilson, Thomas L. Kelly, Joseph M. Massaro, Roger A. Fielding, Jay Magaziner, Rosaly Correa‐de‐Araujo, Timothy C.Y. Kwok, Vasant Hirani, Magnus K. Karlsson, Ralph B. DʼAgostino, Dan Mellström, Claes Ohlsson, Eva Ribom, Joanne M. Jordan, Shalender Bhasin, Peggy M. Cawthon
Institutions: University of Florida, California Pacific Medical Center, University of Pittsburgh, Harvard University, Hebrew SeniorLife, University of Maryland, Baltimore, Hologic (United States), Boston University, Tufts University, National Institutes of Health, National Institute on Aging, Chinese University of Hong Kong, The University of Sydney, Lund University, Skåne University Hospital, University of Gothenburg, Uppsala University, University of North Carolina at Chapel Hill
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Foundation for the National Institutes of Health, U.S. Department of Agriculture, Association of Schools of Public Health, Stiftelsen för Strategisk Forskning, Novo Nordisk, Vetenskapsrådet, Chinese University of Hong Kong, Göteborgs Läkaresällskap, Novo Nordisk Fonden, National Institutes of Health, Centers for Disease Control and Prevention, Medical Research Council, National Health and Medical Research Council, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Advancing Translational Sciences
Awards: G100949702, G1023702118, G1083180012, G1097528416, G1220223050, G125972088, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1338207769, Study of Osteoporotic Fractures, Osteoporotic Fractures in Men (MrOS) - Minneapolis, G1438302022, DYNAMICS OF HEALTH,AGING, AND BODY COMPOSITION, G1493513681, CORONARY HEART DISEASE AND STROKE, G16819465, G1726490033, G177655820, Oregon Clinical and Translational Research Institute, Study of Osteoporotic Fractures, Osteoporatic Fractures in Men (MrOS), DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION, G2194386449, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, Muscle Mass and Strength Cutpoints in Persons at Risk of Mobility Disability, G2391884931, G2404385439, G2439840495, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G2644159154, G270907595, G2800149121, G2815873878, G2899267414, G2906405448, G2929263391, G3045517347, G3137375862, HEALTH ABC--COORDINATING UNIT, G3220743633, Long-term fracture risk in older men: the MrOS study, G3256118428, G3396628412, G34347772, G3466391951, CHS research resources for the cardiovascular health of older adults, Osteoporotic Fractures in Men (Mr. Os) Palo Alto, G3591820528, G3682927731, G3782866490, G3835417588, G3860090032, G3922592609, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G4118007464, G423252844, G4253755194, Study of Osteoporotic Fractures, G4309194208, Osteoporotic Fractures in Men (MrOS) - Administrative Center, G4622379297, Study of Osteoporotic Fractures, G4712859843, Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinic, G4942589162, G5145575165, G5148796768, G5164707915, G5281952516, G537455924, G5411890053, G544148272, G5479317095, Integrative Resource to Develop Translational Strategies to Promote Longevity, G5659566681, G581554933, G581887176, G5909482378, CHS Events Follow-up Study, Concord Hormones and Ageing in Men Project (CHAMP), G6226795708, G6401035755, The Framingham Heart Study, Osteoporotic Fractures in Men (Mr.OS), G6706757010, G670738241, Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating Center, NIAMS Multidisciplinary Clin Res Ctr: Rheumatic Diseases, Study of Osteoporotic Fractures, G6958519851, G6986132784, Osteoporotic Fractures in Men (MrOS) - Portland, G7058527481, G7176672723, G7217924807, Unraveling Musculoskeletal Pleiotropy Using Genome-Wide Association, G7244861316, G7446983892, Osteoporotic fractures in Chinese men: MrOs Hong Kong, G7466862218, Osteoporotic Fractures in Men_MrOS Renewal_Birmingham, G764651519, G766700449, G766843672, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASES CENTER, G8068269535, G8125002010, G8260701975, G8384987212, G8432517111, G8511401681, G8518686724, G854036830, G85598970, G861947890, CHS-Transition Phase -268055222, 4 of 4: Study of Osteoporotic Fractures (SOF), G870807107, G8892155751, G9000027259, G9000046001, G9000124008, G9000125773, G9000139054, G9000155215, Boston OAIC: A Translational Approach to Function Promoting Therapies, Pittsburgh Older Americans Independence Center, University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC), Novel Molecular Biomarkers of Bone Microarchitecture, G945304896, G992156627
OpenAlex ID: W3041684540