Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR
Year: 2020
Type: article
Abstract: The liver hormone hepcidin controls the main inflows of iron into plasma by binding to and inducing the degradation or the occlusion of the iron export activity of ferroportin, the only known cellular exporter of iron. When hepcidin concentrations are high, iron is trapped in enterocytes of the duodenum, hepatocytes, and macrophages. Hepcidin production by the hepatocytes is induced by a number of stimuli, most notably iron, through the BMP-SMAD signaling pathway, and inflammatory signals, through the IL-6/ STAT3 signaling axis. In addition, hepcidin has also been reported to respond to intracellular stress, namely endoplasmic reticulum (ER) stress which is involved in a number of pathophysiological states, including the inflammatory response, nutrient disorders and viral infection. A previous study has suggested that hepcidin induction by ER stress is controlled by the BMP-SMAD pathway,5 but the exact mechanism is still uncertain
Source: Haematologica
Authors: Audrey Belot, Ophélie Gourbeyre, Anais Palin, Aude Rubio, Amélie Largounez, Céline Besson-Fournier, Chloé Latour, Megane Lorgouilloux, Inka Gallitz, Alexandra Montagner, Arnaud Polizzi, Marion Régnier, Sarra Smati, An-Sheng Zhang, Manuel D. Diaz-Munoz, Andrea U. Steinbicker, Hervé Guillou, Marie-Paule Roth, Hélène Coppin, Delphine Meynard
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $379
Awards: Role of iron in the pathogenesis of NASH, Targeting Matriptase-2 to develop new therapeutic strategies for iron related disorders, FGF21 links hepatic ChREBP and PPARa to systemic glucose control, Equipements plateforme animalerie infectieuse de haute-sécurité de Midi Pyrénées, Roles of Neogenin and Matriptase-2 in Iron Homeostasis
OpenAlex ID: W3043839133