Year: 2020
Type: review
Abstract: Thyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional surgical procedures to obtain a final diagnosis. It is, therefore, necessary to seek more reliable markers to complement and improve current methods. "Omics" approaches have gained much attention in the last decade in the field of biomarker discovery for diagnostic and prognostic characterisation of various pathophysiological conditions. Metabolomics, in particular, has the potential to identify molecular markers of thyroid cancer and identify novel metabolic profiles of the disease, which can, in turn, help in the classification of pathological conditions and lead to a more personalised therapy, assisting in the diagnosis and in the prediction of cancer behaviour. This review considers the current results in thyroid cancer biomarker research with a focus on metabolomics.
DOI: 10.3390/ijms21155272
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,112
Awards: G1167214205, G1516346500, G1577006909, G1578237752, G1763632427, G196013823, Distúrbios afetivos: biomarcadores e deteção precoce, G274581676, G2789254993, G3355441032, G3379593517, UID/NEU/04539 .: CNC.IBILI, Além do Beta-Amilóide - As Alterações Patogénicas Precoces na Doença de Alzheimer, High resolution NMR studies of atypia of undertemined signficance (AUS) or follicular lesion of undetermined significance (FLUS) in human thyroid cytological samples, G3840324753, G3891694003, G4015828041, G4724859719, G4728418649, G4852177732, G4879651195, G491858407, G5184632717, G5224927334, G5454278309, G5677667711, G5794836690, Centro de Inovação em Biomedicina e Biotecnologia, Novas abordagens em Encefalopatia hipóxico-isquémica: investigação translacional para diagnosticar e monitorizar resposta a terapia com células estaminais., Redes sinápticas e abordagens compreensivas de medicina personalizada em doenças neurocomportamentais ao longo da vida, G7626508434, G7965899483, G8866612878, G910018558
OpenAlex ID: W3045267286