Work

Pathogenesis of Muscle Weakness in Inflammatory Myositis

Year: 2020

Type: article

Abstract: Idiopathic inflammatory myositis (IIM) is a heterogeneous group of autoimmune diseases. These are characterized by muscle weakness and fatigue along with other systemic manifestations, ranging from pulmonary alveolitis to vasculopathic ulcers. Muscle weakness is encountered in a majority of individuals with IIM. Several hypotheses for muscle weakness have been proposed, but none have been convincingly proven. Understanding of the pathophysiology of muscle weakness is necessary to better delineate therapeutic options and tailor exercise regimens in patients with IIM. In this review, we have attempted to delineate the immune and nonimmune pathways implicated in muscle weakness and integrated them with the clinical, histopathological, and imaging findings in IIM.

Source: Indian Journal of Rheumatology

DOI: 10.4103/injr.injr_120_20

Authors: Sai Kumar Dunga, T. G. Sundaram, Chengappa G. Kavadichanda

Institution: Sanjay Gandhi Post Graduate Institute of Medical Sciences

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3045668143

FWCI: 0.794

Cites: 99

Cited by: 5

Related to: 10