Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model
Year: 2020
Type: article
Abstract: antagonizes the C/EBPβ/AEP axis, mitigating gut leakage and oxidative stress. Our findings support the hypothesis that C/EBPβ/AEP signaling is activated by gut dysbiosis, implicated in AD pathologies in the gut.
Source: Science Advances
Institutions: Emory University, University of Kentucky
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,500
Funders: Emory University, National Institutes of Health, School of Medicine, Emory University, National Institute on Aging, NIH Office of the Director, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences
Awards: G2289923368, The Molecular Mechanism and Therapeutics in Axon Regeneration, G4160209598, Emory Neuroscience NINDS Core Facilities (ENNCF), Impact of dysbiotic and symbiotic catabolism of luminal amino acids on intestinal epithelial barrier function and inflammation, Microbially generated protons mediate interkingdom host-microbiome cross-talk and maintain intestinal homeostasis via reciprocal functions of two proton-sensing GPCRs, G7184825401, Molecular Regulation of AEP during Ageing, COBRE for Translational Chemical Biology, Georgia Clinical & Translational Science Alliance (Georgia CTSA)
OpenAlex ID: W3045674263