Clinical Outcomes of Endoscopic Resection for Low-Grade Dysplasia and High-Grade Dysplasia on Gastric Pretreatment Biopsy: Korea ESD Study Group
Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUND/AIMS: Some cases of gastric low-grade dysplasia (LGD) and high-grade dysplasia (HGD) on forceps biopsy (FB) are diagnosed as gastric cancer (GC) after endoscopic resection (ER). This study aims to evaluate the clinical outcomes of ER for gastric LGD and HGD on pretreatment FB and to identify the factors that predict pathologic upstaging to GC. METHODS: Patients who underwent ER for LGD and HGD on pretreatment FB from March 2005 to February 2018 in 14 hospitals in South Korea were enrolled, and the patients' medical records were reviewed retrospectively. RESULTS: infection, smoking history, tumor location in the lower third of the stomach, tumor size >10 mm, depressed lesion, and ulceration were significantly associated with GC. As the number of risk factors predicting GC increased in both LGD and HGD on pretreatment FB, the rate of upstaging to GC after ER increased. CONCLUSIONS: A substantial proportion of LGDs and HGDs on pretreatment FB were diagnosed as GC after ER. Accurate ER procedures such as endoscopic submucosal dissection should be recommended in cases of LGD and HGD with factors predicting pathologic upstaging to GC.
Source: Gut and Liver
DOI: 10.5009/gnl19275
Institutions: Kyung Hee University Hospital at Gangdong, Konyang University, Kyung Hee University, Catholic University of Korea, Soonchunhyang University, Soonchunhyang University Hospital Bucheon, National Cancer Center, National Cancer Center Hospital, Kyungpook National University, Yeungnam University Medical Center, Yeungnam University College, Yeungnam University, Chungnam National University, Chungnam National University Hospital, Hallym University, Hallym University Chuncheon Sacred Heart Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3048755313