Year: 2020
Type: article
Abstract: Recent high-throughput approaches have revealed a vast number of transcripts with unknown functions. Many of these transcripts are long noncoding RNAs (lncRNAs), and intergenic region-derived lncRNAs are classified as long intergenic noncoding RNAs (lincRNAs). Although Myosin heavy chain 6 (Myh6) encoding primary contractile protein is down-regulated in stressed hearts, the underlying mechanisms are not fully clarified especially in terms of lincRNAs. Here, we screen upregulated lincRNAs in pressure overloaded hearts and identify a muscle-abundant lincRNA termed Lionheart. Compared with controls, deletion of the Lionheart in mice leads to decreased systolic function and a reduction in MYH6 protein levels following pressure overload. We reveal decreased MYH6 results from an interaction between Lionheart and Purine-rich element-binding protein A after pressure overload. Furthermore, human LIONHEART levels in left ventricular biopsy specimens positively correlate with cardiac systolic function. Our results demonstrate Lionheart plays a pivotal role in cardiac remodeling via regulation of MYH6.
Source: Communications Biology
Authors: Yasuhide Kuwabara, Shuhei Tsuji, Masataka Nishiga, Masayasu Izuhara, Shinji Ito, Kazuya Nagao, Takahiro Horie, Shin Watanabe, Satoshi Koyama, Hisanori Kiryu, Yasuhiro Nakashima, Osamu Baba, Tetsushi Nakao, Tomohiro Nishino, Naoya Sowa, Yui Miyasaka, Takeshi Hatani, Yuya Ide, Fumiko Nakazeki, Masahiro Kimura, Yoshinori Yoshida, Tsukasa Inada, Takeshi Kimura, Koh Ono
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,290
Awards: Development of a novel therapeutic drug for the treatment of heart failure by cell protection, An integrated approach for cell cycle control of pluripotent stem cell-derived cardiomyocytes, G3130879173, G365510092, G3687414292, G561986750, Elucidation of the functions of long non-coding RNA in cardiovascular diseases, Establishing statistical inference theory for bio-systems and biological control theory using control engineering, 心肥大、心不全における非コードＲＮＡの機能解析, G7663179502, 心肥大で誘導される新規lincRNAの、筋組織における核内制御と核内機能の解明
OpenAlex ID: W3048867355