Year: 2020
Type: review
Abstract: The therapeutic potential of mesenchymal stem cells (MSCs) has been investigated in many preclinical and clinical studies. This potential is dominantly based on the immunosuppressive properties of MSCs. Although the therapeutic profiles of MSC transplantation are still not fully characterized, accumulating evidence has revealed that B cells change after MSC infusion, in particular inducing regulatory B cells (Bregs). The immunosuppressive effects of Bregs have been demonstrated, and these cells are being evaluated as new targets for the treatment of inflammatory diseases. MSCs are capable of educating B cells and inducing regulatory B cell production via cell-to-cell contact, soluble factors, and extracellular vesicles (EVs). These cells thus have the potential to complement each other's immunomodulatory functions, and a combined approach may enable synergistic effects for the treatment of immunological diseases. However, compared with investigations regarding other immune cells, investigations into how MSCs specifically regulate Bregs have been superficial and insufficient. In this review, we discuss the current findings related to the immunomodulatory effects of MSCs on regulatory B cells and provide optimal strategies for applications in immune-related disease treatments.
Source: Frontiers in Immunology
Authors: Jialing Liu, Qiuli Liu, Xiaoyong Chen
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Funders: National Natural Science Foundation of China, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities, National Key Research and Development Program of China Stem Cell and Translational Research, Basic and Applied Basic Research Foundation of Guangdong Province
Awards: G1809309883, BCR-钙信号通路在间质干细胞诱导调节性B细胞治疗cGVHD中的作用机制研究, G2019582475, G2679234170, G3257465046, G3469898941, G3605034449, 间质干细胞治疗慢性移植物抗宿主病的免疫作用机制, G4454428168, G4696127109, G4803601063, G5691270697, G5918106564, G6017193691, G603894561, G6312753438, G6515870583, G8210328061, G86085368, G99900796
OpenAlex ID: W3049436600