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Optimal Dosing of Ceftriaxone in Infants Based on a Developmental Population Pharmacokinetic-Pharmacodynamic Analysis

Year: 2020
Type: article
Abstract: Ceftriaxone is a third-generation cephalosporin used to treat infants with community-acquired pneumonia. Currently, there is a large variability in the amount of ceftriaxone used for this purpose in this particular age group, and an evidence-based optimal dose is still unavailable. Therefore, we investigated the population pharmacokinetics of ceftriaxone in infants and performed a developmental pharmacokinetic-pharmacodynamic analysis to determine the optimal dose of ceftriaxone for the treatment of infants with community-acquired pneumonia.
DOI: 10.1128/aac.01412-20
Authors: Ya-Kun Wang, Yue-E Wu, Xue Li, Li-Yuan Tian, Muhammad Wasim Khan, Bo-Hao Tang, Hai-Yan Shi, Yi Zheng, Guo-Xiang Hao, John van den Anker, Dian-Ping You, Wei Zhao
Institutions: Hospital of Hebei Province, Shandong University, Shandong Provincial QianFoShan Hospital, Shandong First Medical University, Children's National, George Washington University, University Hospital of Basel, University Children’s Hospital Basel
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W3051626514
FWCI: 0.95
Cites: 31
Cited by: 14
Related to: 10