Genetic Variants in miRNAs Are Associated With Risk of Non-syndromic Tooth Agenesis

Year: 2020

Type: article

Abstract: Non-syndromic tooth agenesis (NSTA) is one of the most common dental abnormalities. MiRNAs participated in the craniofacial and tooth development. Therefore, single nucleotide polymorphisms (SNPs) in miRNA genes may contribute to the susceptibility of NSTA. Here, a total of 625 NSTA cases and 1,144 healthy controls were recruited, and four miRNA SNPs (miR146a/rs2910164, miR-196a2/rs11614913, pre-miR-605/rs2043556, pre-miR-618/rs2682818) were genotyped by the TaqMan platform. Rs2043556 showed nominal associations with risk of NSTA (P Add =0.021) in the overall analysis, as well as upper lateral incisor agenesis (P Add =0.047) and lower incisor agenesis (P Add =0.049) in the subgroup analysis. Notably, its significant association with upper canine agenesis was observed (P Add =0.0016). Rs2043556 affected the mature of miR-605-3p and miR-605-5p while dual-luciferase report analysis indicated that MDM2 was the binding target of miR-605-5p. Our study indicated that pre-miR-605 rs2043556 was associated with risk of NSTA.

Source: Frontiers in Physiology

DOI: 10.3389/fphys.2020.01052

Authors: Min Gu, Xin Yu, Liwen Fan, Guirong Zhu, Fan Yang, Shu Lou, Lan Ma, Yongchu Pan, Lin Wang

Institutions: Soochow University, The First People's Hospital of Changzhou, Nanjing Medical University, State Key Laboratory of Reproductive Medicine

Language: English

Topic: dental development and anomalies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950

Funders: National Natural Science Foundation of China, Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province, Nanjing Medical University, Priority Academic Program Development of Jiangsu Higher Education Institutions, Qinglan Project of Jiangsu Province of China

OpenAlex ID: W3081007485