Work

miRNA-Based Therapies in B Cell Non-Hodgkin Lymphoma

Year: 2020

Type: review

Abstract: Non-Hodgkin lymphoma (NHL) is a diverse class of hematological cancers, many of which arise from germinal center (GC)-experienced B cells. Thus GCs, the sites of antibody affinity maturation triggered during immune responses, also provide an environment that facilitates B cell oncogenic transformation. miRNAs provide attractive and mechanistically different strategies to treat these malignancies based on their potential for simultaneous modulation of multiple targets. Here, we discuss the scientific rationale for miRNA-based therapeutics in B cell neoplasias and review recent advances that may help establish a basis for novel candidate miRNA-based therapies for B cell-NHL (B-NHL).

Source: Trends in Immunology

DOI: 10.1016/j.it.2020.08.006

Authors: Teresa Fuertes, Almudena R. Ramiro, Virginia G. de Yebenes

Institutions: Spanish National Centre for Cardiovascular Research, Universidad Complutense de Madrid, Research Institute Hospital 12 de Octubre

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,000