Work

Study on Preparation of Y-90 Microspheres in Da Lat Nuclear Reactor for Application in Treatment of Primary and Secondary Liver Cancers

Year: 2020

Type: article

Abstract: In this article, Y-90 microspheres are synthesized in three forms (resin microspheres, glass microspheres and gel microspheres) in Da Lat Nuclear Reactor (Vietnam) with a capacity of 500 kW for application in treatment of primary and secondary liver cancers.Characterization and quality of Y-90 microspheres are checked by field emission scanning electron microscopy (FE-SEM), energydispersive X-ray spectroscopy (EDX), chemical purity, radionuclide purity, radiochemical purity, sterility, bacterial endotoxins, toxic heavy metals (ICP-MS) and product stability over time.The results showed that Y-90 resin microspheres, Y-90 glass microspheres and Y-90 gel microspheres with particle sizes of 20-30 µm have a high specific activity to meet the quality standards of radiopharmaceuticals according to British Pharmacopoeia 2016.This is a promising radiopharmaceuticals in treatment of primary and secondary liver cancers using radioembolization in Vietnam.

Source: Oriental Journal Of Chemistry

DOI: 10.13005/ojc/360414

Authors: Pham Thanh Minh, Duong Van Dong, Le Van Thuan, Truong Minh Tri, Truong Duc Toan, Cao Dong Vu