Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease
Year: 2020
Type: review
Abstract: infection (CDI). The success of FMT for CDI has led to interest in its therapeutic potential in many other disorders. The mechanisms that underpin the efficacy of FMT are not fully understood. Importantly, FMT remains a crucial treatment in managing CDI and understanding the mechanisms that underpin its success will be critical to improve its clinical efficacy, safety and usability. Furthermore, a deeper understanding of this may allow us to expose FMT's full potential as a therapeutic tool for other disease states. This review will explore the current understanding of the mechanisms underlying the efficacy of FMT across a variety of diseases.
Institutions: Imperial College Healthcare NHS Trust, St Mary's Hospital, Imperial College London, University Hospitals Birmingham NHS Foundation Trust, University of Birmingham, Cardiff University, Inserm, AgroParisTech, Microbiologie de l’alimentation au service de la santé, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Antoine, Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine, Centre de Recherche Saint-Antoine
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,200
Award: G3665202723
OpenAlex ID: W3083313199