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Cryptococcus gattii and its Distinctive Yeast Morphology in Cerebrospinal Fluid Cytology

Year: 2020

Type: article

Abstract: A 30-year-old immunocompetent male with no significant medical history presented with 4 weeks history of somnolence, fatigue, poor appetite, fever, headache, neck stiffness, and nausea.Subsequent brain magnetic resonance imaging indicated numerous subcentimeter foci of diffusion restriction, mainly in the bilateral putamina and caudates, but also in the bilateral posterior limbs of the internal capsules and periventricular.Cerebrospinal fluid (CSF) cytology evaluation demonstrated clusters of brown-pigmented, oval-and tear-drop-shaped budding, yeasts along with elevated lymphocyte and monocyte counts.The morphology was not characteristic of Cryptococcus neoformans yeast.CSF was sent for fungal culture and grew Cryptococcus gattii.The patient was treated with induction therapy with amphotericin B (4 mg/kg) and flucytosine (25 mg/kg Q6H).

Source: Journal of Pathology and Infectious Diseases

DOI: 10.33309/2639-8893.030102

Authors: Hirad Hosseini, Cassiana Bittencourt, Sonia Lee, Di Lu, Min Han

Institutions: University of California, Irvine, University of California, Irvine Medical Center, UC Irvine Health

Language: English

Topic: Fungal Infections and Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3083329083

FWCI:

Cites: 14

Cited by: 1

Related to: 10