Work

Antioxidant and cytotoxic activities of the ethyl acetate extract of Sphagneticola trilobata (L.) J.F. Pruski on MCF-7 breast cancer cell

Year: 2020

Type: article

Abstract: Sphagneticola trilobata (L.) J.F. Pruski is the perennial herb distributed at tropical temperature. In this study, the antioxidant and anticancer properties of the ethyl acetate extract from S. trilobata leaves were investigated against MCF-7 breast cancer cells. The antioxidant and anticancer activities were assessed by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay methods, respectively. The extract demonstrated DPPH free radical scavenging effect with IC50value equaling to 127.43 μg/mL. The cytotoxic study was conducted on the concentration range of 1–200 μg/mL, and the results exhibited the strongest inhibitory activity against MCF-7 with the LC50value of 58.143 μg/mL. The cytotoxic activity of the extract was supported by the induction of apoptosis cell which possessed the apoptosis percentage of 78.80%. Thus, the cheap herbal drug treatment might highly be recommended to treat effectively breast cancers as an ideal choice or combinational therapy.

Source: Journal of Advanced Pharmaceutical Technology amp Research

DOI: 10.4103/japtr.japtr_31_20

Authors: Syafruddin Ilyas, Vivi Mardina, Tisna Harmawan, Halimatussakdiah Halimatussakdiah, Masitta Tanjung

Institutions: Universitas Sumatera Utara, Samudra University

Language: English

Topic: Medicinal Plant Research

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $500