The New Coronavirus (SARS-CoV-2): A Comprehensive Review on Immunity and the Application of Bioinformatics and Molecular Modeling to the Discovery of Potential Anti-SARS-CoV-2 Agents
Year: 2020
Type: article
Abstract: On March 11, 2020, the World Health Organization (WHO) officially declared the outbreak caused by the new coronavirus (SARS-CoV-2) a pandemic. The rapid spread of the disease surprised the scientific and medical community. Based on the latest reports, news, and scientific articles published, there is no doubt that the coronavirus has overloaded health systems globally. Practical actions against the recent emergence and rapid expansion of the SARS-CoV-2 require the development and use of tools for discovering new molecular anti-SARS-CoV-2 targets. Thus, this review presents bioinformatics and molecular modeling strategies that aim to assist in the discovery of potential anti-SARS-CoV-2 agents. Besides, we reviewed the relationship between SARS-CoV-2 and innate immunity, since understanding the structures involved in this infection can contribute to the development of new therapeutic targets. Bioinformatics is a technology that assists researchers in coping with diseases by investigating genetic sequencing and seeking structural models of potential molecular targets present in SARS-CoV2. The details provided in this review provide future points of consideration in the field of virology and medical sciences that will contribute to clarifying potential therapeutic targets for anti-SARS-CoV-2 and for understanding the molecular mechanisms responsible for the pathogenesis and virulence of SARS-CoV-2.
Source: Molecules
Authors: Gustavo R. Villas-Boas, Vanessa C. Rescia, Marina M. Paes, Stefânia N. Lavorato, Manoel F. de Magalhães-Filho, Mila S. Cunha, Rafael da C. Simões, Roseli B. de Lacerda, Renilson S. de Freitas-Júnior, Bruno H. da S. Ramos, Ana M. Mapeli, Matheus da S. T. Henriques, William R. de Freitas, Luiz A. F. Lopes, Luiz G. R. Oliveira, Jonatas G. da Silva, Saulo E. Silva-Filho, Ana P. S. da Silveira, Katyuscya V. Leão, Maria M. de S. Matos, Jamille S. Fernandes, Roberto K. N. Cuman, Francielli M. de S. Silva-Comar, Jurandir F. Comar, Luana do A. Brasileiro, Jussileide N. dos Santos, Silvia A. Oesterreich
Institutions: Universidade Federal do Oeste da Bahia, Universidade Federal do Paraná, Universidade Federal do Rio de Janeiro, Universidade Federal do Sul da Bahia, Universidade Federal da Grande Dourados, Universidade Federal de Mato Grosso do Sul, Centro Universitário da Grande Dourados, Centro Universitário Unigran Capital, Faculdade de Medicina do ABC, Universidade Estadual de Maringá, Instituto Nacional de Câncer - INCA
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,112
OpenAlex ID: W3083344141