Circulating metabolites are associated with brain atrophy and white matter hyperintensities
Year: 2020
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). METHODS: We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. RESULTS: Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. DISCUSSION: Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.12180
Authors: Francisca A. de Leeuw, Hata Karamujić‐Čomić, Betty M. Tijms, Carel F.W. Peeters, Maartje I. Kester, Philip Scheltens, Shahzad Ahmad, Dina Vojinovic, Hieab H.H. Adams, Thomas Hankemeier, Daniel Bos, Aad van der Lugt, Meike W. Vernooij, M. Arfan Ikram, Najaf Amin, Frederik Barkhof, Charlotte E. Teunissen, Cornelia M. van Duijn, Wiesje M. van der Flier
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
OpenAlex ID: W3083370456