Work

Effect of brefelamide on growth factor-induced cell proliferation in 1321N1 human astrocytoma cells

Year: 2018

Type: article

Abstract: Background: Gliomas arising from glial cells are typical tumors of the central nervous system, and they express various growth factors and their corresponding receptors, which together contribute to malignancy. Brefelamide is a novel aromatic amide isolated from Dictyostelium cellular slime molds. We found that brefelamide has a potent growth inhibitory effect in 1321N1 human astrocytoma cells, but not in PC12 cells. In the present study, we examined the mechanism by which brefelamide inhibited the proliferation of 1321N1 human astrocytoma cells.

Source: Proceedings for Annual Meeting of The Japanese Pharmacological Society

DOI: 10.1254/jpssuppl.wcp2018.0_po1-1-109

Authors: Shigeyoshi Honma, Takahiro Shibuya, Takahiro Ishikawa, Sachina Takasaka, Keita Kouno, Makoto Yoshida

Institution: Takasaki University of Health and Welfare

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3084048769

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