Work

The transgenerational inheritance of reduced memory and recognition in prenatal valproic acid-exposed mice model of autism spectrum disorder

Year: 2018

Type: article

Abstract: Background: Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by two core behavioral symptoms of social deficits and stereotyped/repetitive behaviors. Both genetic and environmental factors are involved in the pathogenesis of ASD. Environmental factors include prenatal exposure to drugs, such as valproic acid (VPA) which is an antiepileptic drug and histone deacetylase (HDAC) inhibitor. HDAC inhibition causes the changes in gene expression of ASD-related molecules. We investigated whether behavioral deficits in prenatally VPA-exposed ASD model mice are transmitted to the next generation (F2).

Source: Proceedings for Annual Meeting of The Japanese Pharmacological Society

DOI: 10.1254/jpssuppl.wcp2018.0_po3-1-62

Authors: Misato Yoshikawa, Hiroaki Aso, Masahiko Watanabe, Katsuya Suemaru

Institution: Shujitsu University

Language: English

Topic: Autism Spectrum Disorder Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3084091826

FWCI:

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