Clinical Significance of CD147 in Children with Inflammatory Bowel Disease

Year: 2020

Type: article

Abstract: BACKGROUND: CD147/basigin (Bsg), a transmembrane glycoprotein, activates matrix metalloproteinases and promotes inflammation. OBJECTIVE: The aim of this study is to explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD). RESULTS: In addition to monocytes, the clinical analysis showed that there is no significance obtained in leucocyte, neutrophil, eosinophil, basophil, and erythrocyte between IBD and controls. Immunohistochemistry analysis showed that CD147 was increased in intestinal tissue of patients with active IBD compared to that in the control group. What is more, CD147 is involved in intestinal barrier function and intestinal inflammation, which was attributed to the fact that it has an influence on MCT4 expression, a regulator of intestinal barrier function and intestinal inflammation, in HT-29 and CaCO2 cells. Most importantly, serum level of CD147 content is higher in active IBD than that in inactive IBD or healthy control, which could be a biomarker of IBD. CONCLUSION: The data suggested that increased CD147 level could be a biomarker of IBD in children.

Source: BioMed Research International

DOI: 10.1155/2020/7647181

Authors: Hongli Wang, Jun Ye, Ruitao Liu, Guanhua Chen, Junhong Zhao, Ling Huang, Fangying Yang, Musheng Li, Shunxian Zhang, Jingxie, Liya Xiong, Huan Chen, Yuxin Xu, Mingmin Su, Yuanwen Xie, Songyu Li, Fengfeng Zheng, Lanlan Geng, Wanfu Xu, Sitang Gong

Institutions: Jinan University, Guangzhou Women and Children Medical Center, First Affiliated Hospital of Jinan University, Guangzhou Medical University, Fujian Medical University, Cardiff University, Putian University

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680

Funders: National Natural Science Foundation of China, Sun Yat-sen University, Natural Science Foundation of Guangdong Province, Natural Science Foundation of Hainan Province, Guangzhou Municipal Health and Family Planning Commission, Guangzhou Institute of Pediatrics, Guangzhou Women and Childrens Medical Center, Guangzhou Municipal Science and Technology Project

OpenAlex ID: W3085174152