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Manganese-enhanced MRI (MEMRI) in breast and prostate cancers: Preliminary results exploring the potential role of calcium receptors

Year: 2020
Type: article
Abstract: PROCEDURES: To preliminary assess the relationship between Manganese Enhanced Magnetic Resonance Imaging (MEMRI) and the expression of calcium receptors in human prostate and breast cancer animal models. METHODS: NOD/SCID mice were inoculated with MDA-MB-231 breast cancer cells and prostate PC3 cancer cells to develop orthotopic or pseudometastatic cancer animal models. Mice were studied on a clinical 3T scanner by using a prototype birdcage coil before and after intravenous injection of MnCl2. Assessment of receptor's status was carried out after the MR images acquisition by immunohistochemistry on excised tumours. RESULTS: Manganese contrast enhancement in breast or prostate cancer animal models well correlated with CaSR expression (p<0.01), whereas TRPV6 expression levels appeared not relevant to the Mn uptake. CONCLUSION: Our preliminary results suggest that MEMRI appears an efficient tool to characterize human breast and prostate cancer animal models in the presence of different expression level of calcium receptors.
Source: PLoS ONE
DOI: 10.1371/journal.pone.0224414
Authors: Gabriella Baio, Marina Fabbi, Michele Cilli, Francesca Rosa, Simona Boccardo, Francesca Valdora, Sandra Salvi, Luca Basso, Laura Emionite, Eliana Gianolio, Silvio Aime, Carlo Emanuele Neumaier
Institutions: University of East Anglia, Norfolk and Norwich University Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust, Ospedale Policlinico San Martino, University of Genoa, University of Turin
Language: English
Open Access status: gold
Estimated APC paid: $1,695
OpenAlex ID: W3087500301
FWCI: 0.28
Cites: 49
Cited by: 6
Related to: 10