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Genetic Features Leading to Reduced Susceptibility to Aztreonam-Avibactam among Metallo-β-Lactamase-Producing Escherichia coli Isolates

Year: 2020

Type: article

Abstract: Metallo-β-lactamase (MBL)-producing Escherichia coli isolates resistant to the newly developed β-lactam/β-lactamase inhibitor drug combination aztreonam-avibactam (ATM-AVI) have been reported. Here, we analyzed a series of 118 clinical MBL-producing E. coli isolates of various geographical origins for susceptibility to ATM-AVI. The nature of the PBP3 protein sequence and the occurrence of bla CMY genes for susceptibility to ATM-AVI were investigated.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01659-20

Authors: Mustafa Sadek, Mario Juhas, Laurent Poirel, Patrice Nordmann

Institutions: University of Fribourg, Inserm, Infection, Anti-microbiens, Modélisation, Evolution

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Microbiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Université de Fribourg