The glymphatic system and its role in cerebral homeostasis
Year: 2020
Type: article
Abstract: The brain's high bioenergetic state is paralleled by high metabolic waste production. Authentic lymphatic vasculature is lacking in brain parenchyma. Cerebrospinal fluid (CSF) flow has long been thought to facilitate central nervous system detoxification in place of lymphatics, but the exact processes involved in toxic waste clearance from the brain remain incompletely understood. Over the past 8 yr, novel data in animals and humans have begun to shed new light on these processes in the form of the "glymphatic system," a brain-wide perivascular transit passageway dedicated to CSF transport and interstitial fluid exchange that facilitates metabolic waste drainage from the brain. Here we will discuss glymphatic system anatomy and methods to visualize and quantify glymphatic system (GS) transport in the brain and also discuss physiological drivers of its function in normal brain and in neurodegeneration.
Source: Journal of Applied Physiology
Institutions: Yale University, Stony Brook University, University of Edinburgh
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Understanding the role of the perivascular space in cerebral small vessel disease, Nitric oxide-mediated changes in glymphatic and CSF systems in aging and Alzheimer’s disease, Characterizing the glymphatic peri-vascular connectome and its disruption in AD, G4490750146, Glymphatic function in a transgenic rat model of Alzheimer's disease, Yale Clinical and Translational Science Award
OpenAlex ID: W3090140697