Year: 2020
Type: article
Abstract: Prostate cancer is a common type of cancer among men. Recently, studies on new anticancer agents of herbal origin in the treatment of cancer have increased. Haplophyllum buxbaumii (HP) is a perennial herbaceous plant. Studies have reported that Haplophyllum subspecies has antioxidant properties. And the anticancer effect of HP is unknown. This study aims to reveal the apoptotic effect HP on prostate cancer. The cytotoxic effect of HP was evaluated by the MTT method. In addition, apoptotic pathway mediators were analyzed by ELISA method. HP extract application reduced the viability of prostate cancer and activated the apoptotic mediators while decreasing anti-apoptotic mediators. Our study showed that HP extract has an antiproliferative and apoptotic effect on prostate cancer.
Authors: Hatem KAZİMOGLU, Halil Mahir KAPLAN
Institutions: Sanko University, Cukurova University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W3090396178