A universal system for digitization and automatic execution of the chemical synthesis literature
Year: 2020
Type: article
Abstract: Robotic systems for chemical synthesis are growing in popularity but can be difficult to run and maintain because of the lack of a standard operating system or capacity for direct access to the literature through natural language processing. Here we show an extendable chemical execution architecture that can be populated by automatically reading the literature, leading to a universal autonomous workflow. The robotic synthesis code can be corrected in natural language without any programming knowledge and, because of the standard, is hardware independent. This chemical code can then be combined with a graph describing the hardware modules and compiled into platform-specific, low-level robotic instructions for execution. We showcase automated syntheses of 12 compounds from the literature, including the analgesic lidocaine, the Dess-Martin periodinane oxidation reagent, and the fluorinating agent AlkylFluor.
Source: Science
Institution: University of Glasgow
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G1449252721, 3DSynth: Design and fabrication of cartridges for digital chemical synthesis, G1683728384, International Collaboration in Chemistry - Modular microtubular architectures for photo-driven water splitting, G324869332, Energy and the Physical Sciences: Hydrogen Production using a Proton Electron Buffer, G3560419251, G5157618558, G5486013847, Molecular-Metal-Oxide-nanoelectronicS (M-MOS): Achieving the Molecular Limit, G6188963204, G6278267844, G6922836983, G692544956, CHEMIFY: A System to Produce Universal Digital Chemical Synthesis, Programmable Molecular Metal Oxides (PMMOs): From Fundamentals to Application, Programmable 'Digital' Synthesis for Discovery & Scale-up of Molecules, Clusters & Nanomaterials, G8482917402, The Multicorder
OpenAlex ID: W3091684735