Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
Year: 2020
Type: article
Abstract: Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.12157
Authors: Berislav V. Zlokovic, Rebecca F. Gottesman, Kenneth E. Bernstein, Sudha Seshadri, Ann McKee, Heather Snyder, Steven M. Greenberg, Kristine Yaffe, Chris B. Schaffer, Chun Yuan, Timothy M. Hughes, Mat J. Daemen, Jeff D. Williamson, Hector M. González, Julie Schneider, Cheryl L. Wellington, Zvonimir S. Katusic, Luke Stoeckel, James I. Koenig, Roderick A. Corriveau, Lawrence Fine, Zorina S. Galis, Jared Reis, Jacqueline D. Wright, Jue Chen
Institutions: University of Southern California, Johns Hopkins University, Cedars-Sinai Medical Center, Boston University, The University of Texas at San Antonio Health Science Center, VA Boston Healthcare System, Alzheimer's Association, Harvard University, Massachusetts General Hospital, University of California, San Francisco, Cornell University, University of Washington, Wake Forest University Health Sciences, Wake Forest University, Amsterdam University Medical Centers, University of Amsterdam, University of California San Diego, Rush University, University of British Columbia, University of British Columbia, Okanagan Campus, Mayo Clinic, National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Heart, Lung, and Blood Institute
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institute on Aging
Award: G219693323
OpenAlex ID: W3091838285