Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019
Year: 2020
Type: article
Abstract: Invasive infection caused by Streptococcus pyogenes emm 89 strains has been increasing in several countries linked to a recently emergent clade of emm 89 strains, designated clade 3. In Japan, the features of emm 89 S. pyogenes strains, such as clade classification, remains unknown. In this study, we collected emm 89 strains isolated from both streptococcal toxic shock syndrome (STSS) (89 STSS isolates) and noninvasive infections (72 non-STSS isolates) in Japan from 2011 to 2019, and conducted whole-genome sequencing and comparative analysis, which resulted in classification of a large majority into clade 3 regardless of disease severity. In addition, invasive disease-associated factors were found among emm 89 strains, including mutations of control of virulence sensor, and absence of the hylP1 gene encoding hyaluronidase. These findings provide new insights into genetic features of emm 89 strains.
Source: Infectious Microbes & Diseases
Authors: Yujiro Hirose, Masaya Yamaguchi, Norihiko Takemoto, Tohru Miyoshi-Akiyama, Tomoko Sumitomo, Masanobu Nakata, Tadayoshi Ikebe, Tomoki Hanada, Takahiro Yamaguchi, Ryuji Kawahara, Rumi Okuno, Hitoshi Otsuka, Yuko Matsumoto, Yuji Terashima, Yu Kazawa, Noriko Nakanishi, Kaoru Uchida, Yumi Akiyama, Kaori Iwabuchi, Chikara Nakagawa, Kazunari Yamamoto, Victor Nizet, Shigetada Kawabata
Institutions: University of California San Diego, The University of Osaka, National Center for Global Health and Medicine, Kagoshima University, National Institute of Infectious Diseases, Osaka Institute of Public Health, Tokyo Metropolitan Institute of Public Health, Yamaguchi Prefectural Institute of Public Health and Environment, Yokohama City Institute of Public Health, Fukushima Institute of Public Health, Kobe Institute of Health, Toyama Institute of Health, Hyogo Prefectural Institute of Environmental Sciences, Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Kyoto City Institute of Health and Environmental Sciences, Niigata City Institute of Public Health and Environment
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,800
Awards: The oral microbiome analysis of healthy children in Thailand and metagenome-wide association analysis, G1540476206, Elucidation of the mechanism of the invasive infection caused by Streptococcus pyogenes and search for novel vaccine antigens, Molecular mechanisms underlying streptococcal infections for development of preventive and therapeutic measures, インフルエンザウイルス感染に続発する細菌性肺炎の重症化に寄与する宿主・細菌因子群の探索と新規感染制御法の開発, Single-cell analysis of the host transcriptional response during pneumococcal infection, Investigation of novel infection control strategy based on bacterial evolutional information, Broad recognition of group A Streptococcus M proteins, Exploration of novel regulatory mechanisms of translation in bacteria, Identifying the Most Effective Adjuvant(s) for Leading Group A Streptococcal Vaccine Antigens in Preclinical Mouse and Nonhuman Primate Models
OpenAlex ID: W3094017648